Gestational diabetes & diabetes in pregnancy
Metabolomic profiling reveals early biomarkers of gestational diabetes mellitus and associated hepatic steatosis
Authors' conclusion
Women who developed GDM exhibited altered metabolomic profiles from early pregnancy, which showed a significant correlation with GDM, with MASLD as a mediator. Selected metabolomic biomarkers may serve as predictive markers and potential targets for early risk assessment and intervention in GDM.
Study context
- Population
- Pregnant women; maternal serum sampled in 1st (10–14 gestational weeks) and 2nd (24–28 gestational weeks) trimesters
- Participants
- 118 vs 118
- Comparison
- Women who developed gestational diabetes mellitus (GDM) vs matched controls
- GDMn = 118
- Controlsn = 118reference
- Outcome
- Early metabolomic biomarkers of GDM and their association with hepatic steatosis (MASLD)
Methodological detailsmatched controls, mediation analysis, prediction model
- Matched controls
- Mediation analysis
- Prediction model
Main finding
As reported in the abstract
Glycocholic acid: indirect effect on GDM incidence mediated by hepatic steatosis, proportion mediated
31.9%
Butanoyl carnitine: proportion mediated
25.7%
Uric acid: proportion mediated
22.4%
Mediation proportions by MASLD ranged
9.7 to 31.9%
Observational data: associations, not effects.
Further findings
Prediction of GDM: refined model (clinical factors + selected 1st-trimester metabolites) vs established model (clinical factors only) · first trimester
- AUC, refined vs established model
- 0.85 vs. 0.63, p < 0.001
Original publication
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