Surgical treatment of cystic pituitary adenomas: literature-based definitions and postoperative outcomes
Authors' conclusion
Despite some individual studies describing a significant influence of pituitary adenoma texture on postoperative outcomes, meta-analyses revealed no such differences between cystic and non-cystic pituitary adenomas. This discrepancy may be explained in part by the inconsistent definition of 'cystic' and between-group differences in tumor size. A notion of a field-standard definition of 'cystic' among pituitary adenomas should be established to facilitate inter-study comparisons.
Study context
- Population
- Surgically treated pituitary adenomas
- Participants
- 283 participants10 studies
- Comparison
- Cystic vs non-cystic pituitary adenomas
- Cysticn = 283
- Outcome
- Postoperative outcomes, cystic vs non-cystic
Methodological detailsPRISMA guidelines, random effects meta-analysis, categorical meta-regressions, Tumor diameter seldom reported with SD/SE, limiting meta-analyses
- PRISMA guidelines
- Random effects meta-analysis
- Categorical meta-regressions
- Tumor diameter seldom reported with SD/SE, limiting meta-analyses
Pooled result
As reported in the abstract
- Cystic vs Non-cystic: P = 0.729
- Cystic vs Non-cystic: P = 0.857
- Cystic vs Non-cystic: P = 0.465
Further pooled results
Outcomes pooled by definition of 'cystic' (visual MRI vs volumetric ≥50%)
- No significant difference in gross total resection
- P = 0.830
- No significant difference in endocrinologic remission
- P = 0.563
- No significant difference in tumor recurrence
- P = 0.320
Original publication
Surgical treatment of cystic pituitary adenomas: literature-based definitions and postoperative outcomes. Pituitary. Published 1 June 2024. doi:10.
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