Slowly progressive type 1 diabetes and female sex as associated factors for pancreatic abnormalities on diagnostic imaging indicating precancerous potential
Authors' conclusion
The findings indicate that slowly progressive type 1 diabetes and female sex are closely associated with PAI, along with age. These results suggest the need for increased clinical vigilance for pancreatic pathology in patients with slowly progressive type 1 diabetes.
Study context
- Population
- Patients with T1D (slowly progressive or acute-onset), Japanese Type 1 Diabetes Database279 screened
- Participants
- 167 patients
- Exposure
- PAI positive vs PAI negative
- PAI positiven = 13
- Outcome
- Factors associated with PAI suggesting precancerous potential
Methodological detailsnationwide cohort, multivariable logistic regression
- Nationwide cohort
- Multivariable logistic regression
Main finding
As reported in the abstract
Factors independently associated with PAI positivity (multivariable logistic regression)
Odds ratio (95% CI)P value
Female sex
13.87(1.6–120.1)
P = 0.017Slowly progressive T1D
5.70(1.46–22.19)
P = 0.012Age
1.05(1.002–1.103)
P = 0.043Observational data: associations, not effects.
Further findings
Female sex
P = 0.007
Slowly progressive T1D
P = 0.034
Older age
- Older age more common in PAI positive vs PAI negative
Original publication
Slowly progressive type 1 diabetes and female sex as associated factors for pancreatic abnormalities on diagnostic imaging indicating precancerous potential. BMJ Open Diabetes Res Care. Published 15 September 2025. doi:10.
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