Rapid and Slow Progressors Toward β-Cell Depletion and Their Predictors in Type 1 Diabetes: Prospective Longitudinal Study in Japanese Type 1 Diabetes (TIDE-J)
Authors' conclusion
This study elucidates the heterogeneity in β-cell dysfunction among Japanese individuals with type 1 diabetes and identifies genetic and clinical predictors of disease progression. These findings provide insights for individualized management strategies and future therapeutic interventions.
Study context
- Population
- Japanese individuals with T1D (TIDE-J database)
- Participants
- 314 individuals
- Exposure
- Acute-onset vs slowly progressive vs fulminant T1D
- Acute-onsetn = 165
- Slowly progressiven = 105
- Fulminantn = 44
- Outcome
- Time to insulin depletion (undetectable C-peptide)
- Follow-up
- Up to 14 years, annual data
Methodological detailsnationwide, multicenter
- Nationwide
- Multicenter
Main finding
As reported in the abstract
Undetectable C-peptide · 5 years after onset
Observational data: associations, not effects.
Further findings
HLA genotype and progression in acute-onset T1D
- Marked interindividual variation in progression toward β-cell depletion within acute-onset T1D
- DR4/DR4 carriers had slower β-cell depletion
- DR4/DR8 and DR4/DR9 associated with rapid progression
Predictors of progression to insulin dependence in slowly progressive T1D
- Low BMI, GAD antibody positivity and absence of DR2 haplotype were predictive
Original publication
Rapid and Slow Progressors Toward β-Cell Depletion and Their Predictors in Type 1 Diabetes: Prospective Longitudinal Study in Japanese Type 1 Diabetes (TIDE-J). Diabetes Care. Published 13 June 2025. doi:10.
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