Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
Authors' conclusion
Despite differences in individual proteins, the combination of multiple biomarkers analyzed by PEA could not distinguish the rate of progression in children with new-onset type 1 diabetes. Only one marker was altered significantly when considering both time and group effects, namely CAR, which increased significantly over time in the rapid group. Nevertheless, we did find some markers that may be useful in predicting the decline of the C-peptide. Moreover, these could potentially be important for understanding type 1 diabetes pathogenesis.
Study context
- Population
- Children (<18 years) with new-onset T1D, included at diagnosis and followed until complete insulinopenia (C-peptide <0.03 nmol/L)46 T1D, 45 controls
- Participants
- 20 / 26 / 45
- Exposure
- Rapid vs slow progressors to complete insulinopenia in new-onset T1D; T1D vs healthy controls
- Rapid progressorsn = 20
- Slow progressorsn = 26
- Healthy controlsn = 45reference
- Outcome
- Biomarkers (proximity extension assay) predictive of rapid or slow disease progression
- Follow-up
- Baseline and
Methodological detailslongitudinal, sex-matched healthy control group
- Longitudinal
- Sex-matched healthy control group
Main finding
As reported in the abstract
Biomarkers higher in rapid group at baseline: carbonic anhydrase 9, corticosteroid 11-beta-dehydrogenase isozyme 1, TNF receptor superfamily member 21
3
Proteins changing over time irrespective of group (linear mixed model)
25
CAR increased over time in rapid progressors
1 protein
Observational data: associations, not effects.
Further findings
- Proteins differing between T1D and healthy controls
- 81
Original publication
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