Skeletal health in adolescents with poorly controlled type 1 diabetes: results from a randomized controlled trial
Authors' conclusion
Despite lower BMD in adolescents with poorly controlled T1D, neither changes in glycemic control nor MG-HI levels correlated significantly with bone health measures, while increase of IGF-1 was associated with BMD accrual. Future studies should explore alternative AGEs and use advanced bone imaging techniques to better understand skeletal fragility in T1D.
Study context
- Population
- Adolescents with poorly controlled T1D (HbA1c >9%/75 mmol/mol); 48.6 % female, mean HbA1c 9.9% (85 mmol/mol), mean age 14.3
- Participants
- 37 adolescents
- Outcome
- Association of glycemic control, IGF-1 and AGEs (MG-HI) with BMD
- Follow-up
- 12 months
Methodological details12-month follow-up
- 12-month follow-up
Main finding
As reported in the abstract
- Increase in IGF-1 associated with bone mineral density (BMD) accrual
- Changes in HbA1c, TIR or methyl-glyoxal-hydro-imidazolone (MG-HI) not associated with BMD accrual
Observational data: associations, not effects.
Further findings
DXA BMD z-scores (lumbar spine, proximal femur, total body less head) vs reference values · baseline
- ≈0.5 SDS lower than reference values
- P = 0.005-0.04
Change in BMD z-scores · 12 months
- Only significant change was an increase in proximal femur in girls
Vertebral fractures
- No vertebral fractures detected
Original publication
Skeletal health in adolescents with poorly controlled type 1 diabetes: results from a randomized controlled trial. BMJ Open Diabetes Res Care. Published 14 September 2025. doi:10.
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