SHBG Gene Polymorphisms and Their Influence on Serum SHBG, Total and Free Testosterone Concentrations in Men
Authors' conclusion
In these men, analyzed SNPs were relatively prevalent and affected serum concentrations of total T and SHBG but not calculated or measured free T except for a higher trend in rs6259 homozygotes.
Study context
- Population
- Healthy men aged 25 to 45 (mean, 34.5) years
- Participants
- 999 men
- Exposure
- SHBG SNP carriers vs wild-type
- Outcome
- Effects of SHBG genetic variation on calculated and measured serum free T
Methodological detailsgenetic association study, Free T measured directly by LC-MS/MS after equilibrium dialysis in a subset (n = 314)
- Genetic association study
- Free T measured directly by LC-MS/MS after equilibrium dialysis in a subset (n = 314)
Main finding
As reported in the abstract
Free T (measured and calculated)
Calculated free T in rs6259 homozygotes vs wild-type
+18.7%
P < .05
Observational data: associations, not effects.
Further findings
Allelic frequencies of analyzed single-nucleotide polymorphism (SNPs)
- Range of allelic frequencies
- 0.5% to 58.2%
SHBG concentrations vs wild-type
- Lower in rs6258 heterozygotes
- −24.7%; P < .05
- Higher in rs6259 heterozygotes, rs727428 homozygotes and rs1799941 carriers
- +10.8 to 23.1%; all P < .05
Total T vs wild-type
- Higher in rs727428 homozygotes and carriers of rs5934505, rs1799941 and rs6259
- +3.9 to 21.4%; all P < .05
Original publication
SHBG Gene Polymorphisms and Their Influence on Serum SHBG, Total and Free Testosterone Concentrations in Men. J Clin Endocrinol Metab. Published 23 April 2024. doi:10.
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