Genital Surgery Outcomes Using an Individualized Algorithm for Hormone Management in Transfeminine Individuals
Authors' conclusion
An individualized algorithm for preoperative hormone management for TF GS resulted in perioperative continuation of GAHT for the majority of individuals without significantly increasing the risk for postoperative surgical complications, while maintaining stable behavioral health measures perioperatively.
Study context
- Population
- Transfeminine individuals undergoing genital surgery with an individualized gender-affirming hormone therapy (GAHT) algorithm, single tertiary referral center, 2017–2022
- Participants
- 183 individuals
- Exposure
- Perioperative estradiol continuation vs temporary preoperative discontinuation
- Group 1n = 138
- Group 2n = 45reference
- Outcome
- VTE incidence, non-VTE postoperative complication incidence, and change in behavioral health assessments
Methodological detailsobservational, single tertiary referral center
- Observational
- Single tertiary referral center
Main finding
As reported in the abstract
VTE
Group 1
0.05%
1
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Baseline characteristicsGroup 2 vs Group 1 · Group 2 statistically older | P < 0.01 |
| Baseline characteristicsGroup 2 vs Group 1 | P < 0.01 |
| Baseline characteristicsGroup 2 vs Group 1 · higher Caprini scores with Group 2 | P < 0.01 |
| Baseline characteristicsGroup 1 vs Group 2 · oral estradiol use more likely with Group 1 | P < 0.01 |
- Baseline characteristics: higher incidence of cardiometabolic comorbidities with Group 2
Safety
- Venous thromboembolism (VTE) · perioperative — Group 1
- 0.05%
VTE · perioperative
- No significant difference in postoperative complications between groups
Original publication
Genital Surgery Outcomes Using an Individualized Algorithm for Hormone Management in Transfeminine Individuals. J Clin Endocrinol Metab. Published 17 April 2024. doi:10.
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