Depression, Anxiety, and Risk of Metabolic Syndrome in Women With Polycystic Ovary Syndrome: A Longitudinal Study
Main finding · Developing MetSynResult — go to the resultAdjusted hazard ratio 1.45 95% CI 1.02–2.06Authors' conclusion
Patients with PCOS and depression and/or anxiety have a high risk of developing MetSyn, with a stronger association between depression and MetSyn. Our findings highlight the urgent need for guideline-directed screening for depression and anxiety at time of diagnosis of PCOS as well as screening at subsequent visits to facilitate risk stratification for metabolic monitoring and early intervention in this high-risk group.
Study context
- Population
- Patients with hyperandrogenic PCOS with at least 2 evaluations for metabolic syndrome (MetSyn) ≥3 years apart, tertiary care ambulatory practice, 2008–2022
- Participants
- 321 patients
- Exposure
- History of depression and/or anxiety vs none
- Outcome
- Risk of developing metabolic syndrome (MetSyn)
- Follow-up
- Median 7 years
Methodological detailslongitudinal, tertiary care ambulatory practice
- Longitudinal
- Tertiary care ambulatory practice
Main finding
Developing MetSyn · during the study period
Adjusted hazard ratio
1.45
95% CI 1.02–2.06
P = 0.04
By group
Depression and/or anxiety
75.3 cases per 100 person-years
Without
47.6 cases per 100 person-years
As reported in the abstract
Observational data: associations, not effects.
Further findings
Developing MetSyn: depression
- Association primarily driven by depression, aHR
- 1.56 (95% CI 1.10-2.20, P = .01)
History of depression and/or anxiety at first visit
- Proportion with history of depression and/or anxiety; a third prescribed antidepressants or anxiolytics
- 33.0%
Original publication
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