Sex hormone binging globulin as an indicator of insulin resistance in type 1 diabetes
Authors' conclusion
In adults with T1D, SHBG decreases with increasing insulin resistance and MetS components. These findings support a potential role for SHBG as a biomarker of metabolic health in T1D, but further studies are needed to determine its clinical utility in identifying individuals who may benefit from interventions targeting insulin sensitivity.
Study context
- Population
- Adults with and without T1D
- Participants
- 102 vs 111
- Exposure
- Adults with T1D vs controls
- T1Dn = 102
- Controlsn = 111reference
- Outcome
- Relationship of circulating SHBG concentration with components of the metabolic syndrome (MetS) and estimated insulin sensitivity (eIS)
Main finding
As reported in the abstract
P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| SHBG with vs without MetS, T1DLower with MetS | Without MetS median 79 (LQ,UQ 46,106) nmol/L | P = 0.007 |
| SHBG with vs without MetS, ControlsLower with MetS | P = 0.03 |
Sex hormone-binding globulin (SHBG) by sex
- SHBG ≈2-fold higher in females than males in both T1D and Controls
- P < 0.0001
Metabolic factors across sex-specific SHBG tertiles
- In both groups, higher SHBG tertiles associated with lower waist-to-hip ratio, waist-to-height ratio, BMI, TG, LDL-C and higher estimated insulin sensitivity (eIS)
- P < 0.05
- SHBG correlated with eIS
SHBG by number of metabolic syndrome (MetS) components
- SHBG decreased with number of MetS components, T1D
- p(trend) = 0.005
- SHBG decreased with number of MetS components, Controls
- p(trend) = 0.0006
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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