Sex Differences in Insulin-Induced Hippocampus Functional Connectivity During Visual Food-Cue Presentation
Authors' conclusion
Central insulin influences hippocampal FC to regions vital for inhibitory control during high-caloric food-cue presentation, implying a potential role of the hippocampal network in modulating insulin's anorexic effects. The observed sex differences between the hippocampus and visual cortex might be influenced by sex hormone action.
Study context
- Population
- Participants aged 21–69 years (30 women); exploratory subset of 13 premenopausal women aged 20–28 years30 women
- Participants
- 60 participants
- Comparison
- Intranasal insulin vs placebo
- Primary endpoint
- Task-based hippocampal FC during food-cue presentation
Methodological detailsrandomized within-subject design, placebo-controlled, fMRI, exploratory analysis in premenopausal women
- Randomized within-subject design
- Placebo-controlled
- fMRI
- Exploratory analysis in premenopausal women
Primary result
As reported in the abstract
Hippocampal FC during food-cue presentation
- Intranasal insulin increased hippocampal functional connectivity (FC) with the prefrontal cortex vs placebo, regardless of sex
- Increase correlated with stronger reduction in subjective hunger and food craving
- Sex × nasal spray interaction: higher hippocampal FC to calcarine gyrus after insulin vs placebo in men, lower response in women
Further findings
Premenopausal women: insulin effect on hippocampus–calcarine gyrus FC and sex hormones · luteal phase
- Insulin effect on hippocampus to calcarine gyrus FC negatively correlated with estradiol/progesterone ratio in the luteal phase
- Exploratory analysis
Original publication
Sex Differences in Insulin-Induced Hippocampus Functional Connectivity During Visual Food-Cue Presentation. J Clin Endocrinol Metab. Published 28 November 2024. doi:10.
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