Autoimmune Disease is Increased in Women With Primary Ovarian Insufficiency
Authors' conclusion
Data confirm increased autoimmune disease in women with POI. The increased risk is largely related to autoimmune polyglandular syndrome types 1 through 4 and autoimmune hypothyroidism. The absence of risk in family members may result from differences in environmental influences or hormone milieu.
Study context
- Population
- Women with primary ovarian insufficiency (POI) and their first-, second- and third-degree relatives; two major Utah healthcare systems serving 85% of the statewomen with POI
- Participants
- 610 women
- Exposure
- Women with POI and their relatives vs population rates
- Women with POIn = 610
- Outcome
- Relative risk of autoimmune disease in women with POI and relatives vs population rates
Methodological detailselectronic health records 1995–2022, genealogy data (Utah Population Database)
- Electronic health records 1995–2022
- Genealogy data (Utah Population Database)
Main finding
As reported in the abstract
Relative risk of autoimmune disease
Women with POI vs Population ratesOdds ratio (95% CI)P value
Autoimmune hypothyroidism
6.88(5.71–8.22)
P < 0.001Adrenal insufficiency
4.72(1.73–10.28)
P = 0.0020T1D
4.13(2.14–7.22)
P = 5.25X10-5Rheumatoid arthritis
5.66(3.10–9.50)
P = 3.70X10-7Vitiligo
15.33(6.16–31.58)
P = 5.25X10-7Celiac disease
7.58(3.47–14.39)
P = 4.47X10-6Psoriasis
3.90(2.01–6.81)
P = 9.04X10-5Systemic lupus erythematosus
4.43(1.63–9.64)
P = 0.0027- At least 1 autoimmune disease in women with POI
- 25%
Observational data: associations, not effects.
Original publication
Autoimmune Disease is Increased in Women With Primary Ovarian Insufficiency. J Clin Endocrinol Metab. Published 28 November 2024. doi:10.
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