Breast Cancer Is Increased in Women With Primary Ovarian Insufficiency
Main finding · Breast cancer in women with POIResult — go to the resultOdds ratio 2.20 95% CI 1.30–3.47Authors' conclusion
Data suggest common genetic risk for POI and reproductive cancers. Tools are needed to predict cancer risk in women with POI and potentially to counsel about risks of hormone replacement therapy.
Study context
- Population
- Women with primary ovarian insufficiency (POI) and their relatives, two major Utah academic health care systems serving 85% of the statewomen with POI
- Participants
- 613 women
- Comparison
- Cancer risk in women with POI and their relatives vs population rates
- POIn = 613
- Outcome
- Relative risk of cancer in women with POI and relatives vs population rates
Methodological detailsrecords 1995–2022, linked to Utah Population Database and Utah Cancer Registry, whole genome sequencing in a subset
- Records 1995–2022
- Linked to Utah Population Database and Utah Cancer Registry
- Whole genome sequencing in a subset
Main finding
Breast cancer in women with POI
Odds ratio
2.20
95% CI 1.30–3.47
P = 0.0023
POIvs Population rates
OR 2.20 (95% CI 1.30–3.47); P = 0.0023
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Breast cancer in second-degree relativesSecond-degree relativesvs Population rates | 1.28 (1.08–1.52) | P = 0.0078 | |
| Colon cancer in second-degree relativesSecond-degree relativesvs Population rates | 1.50 (1.14–1.94) | P = 0.0036 | |
| Prostate cancer in relativesFirst-degree relativesvs Population rates | 1.64 (1.18–2.23) | P = 0.0026 | |
| Prostate cancer in relativesSecond-degree relativesvs Population rates | 1.54 (1.32–1.79) | P < 0.001 | |
| Prostate cancer in relativesThird-degree relativesvs Population rates | 1.33 (1.20–1.48) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Age at diagnosis in probands with POI
- Age at POI diagnosis
- 36.5 ± 4.3 years
- Age at cancer diagnosis
- 59.5 ± 12.7 years
Genetics
- Causal and candidate gene variants for cancer and POI were identified
Original publication
Breast Cancer Is Increased in Women With Primary Ovarian Insufficiency. J Clin Endocrinol Metab. Published 12 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →