Association of standardized serum 25-hydroxyvitamin D with falls in post-menopausal women
Primary result · Falls by s25D groupResult — go to the resultAdjusted OR of ≥ 2 falls 1.99 CI 1.2–3.3Authors' conclusion
s25D up to 60 ng/mL was not associated with greater risk for ≥ 1 or ≥ 2 falls. Women with a s25D ≥ 60 ng/mL were at higher odds for ≥ 2 falls, however this group included only ~ 2% of study observations; therefore, confirmation in other cohorts is necessary.
Study context
- Population
- Postmenopausal women in a 4-year calcium/vitamin D supplementation trial; falls recorded by diary5,732 pooled observations
- Participants
- 2,303 women
- Comparison
- Standardized 25D groups
- Primary endpoint
- Incidence of ≥ 1 fall and ≥ 2 falls by s25D group
- Follow-up
- Years 2-4
Methodological detailsplanned secondary analysis, 4-year trial, pooled data from years 2-4, multivariable logistic regression
- Planned secondary analysis
- 4-year trial
- Pooled data from years 2-4
- Multivariable logistic regression
Primary result
Falls by s25D group
Adjusted OR of ≥ 2 falls
1.99
CI 1.2–3.3
≥ 60 ng/mLvs 30- < 40 ng/mL
adjusted OR of ≥ 2 falls 1.99 (CI 1.2–3.3)
As reported in the abstract
- Incidence of ≥ 1 fall across s25D groups
- 22-32% (p = 0.19)
- Incidence of ≥ 2 falls varied, from 6% (< 20 ng/mL) to 17% (≥ 60 ng/mL)
- P = 0.03
Further findings
ng/mL
- Mean (SD) baseline s25D, no difference between supplement and placebo
- 32.6 (8.3)
- s25D at year 2 in supplement group, then stable
- 41.3
Original publication
Association of standardized serum 25-hydroxyvitamin D with falls in post-menopausal women. Osteoporos Int. Published 25 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →