The Influence of X Chromosome Parent-of-Origin on Glycemia in Individuals with Turner Syndrome
Authors' conclusion
Maternal Xchr monosomy predicts higher glucose concentration than paternal Xchr monosomy in response to oral glucose in 45,X individuals. This effect is obscured when including individuals who are mosaic, potentially due to the presence of both parent Xchrs in the non-45,X cell line.
Study context
- Population
- Individuals with Turner syndrome (TS), 45,X karyotype, from the TS: Genotype Phenotype study, with X chromosome (Xchr) parent-of-origin assessment and a 3-h oral glucose tolerance test (OGTT)45,X karyotype
- Participants
- 81 individuals
- Exposure
- Maternal vs paternal Xchr monosomy
- Outcome
- Incremental area under the glucose curve (iAUC) on OGTT, predicted by Xchr parent-of-origin, age and/or BMI
- Follow-up
- 3-h OGTT
Methodological detailsparallel-slopes multiple linear regression
- Parallel-slopes multiple linear regression
Main finding
As reported in the abstract
Predictors of iAUC glucose (45,X)
Age, β
0.36
p = 0.0004
Body mass index (BMI), β
0.33
p = 0.001
Xchr parent-of-origin, β
0.21
p = 0.01
Observational data: associations, not effects.
Further findings
iAUC glucose including 62 additional individuals with 45,X mosaicism
- Overall model remained statistically significant; Xchr parent-of-origin no longer significant
Original publication
The Influence of X Chromosome Parent-of-Origin on Glycemia in Individuals with Turner Syndrome. Horm Res Paediatr. Published 18 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →