The role of glycated hemoglobin in the diagnosis of prediabetes and diabetes mellitus in young women with polycystic ovary syndrome
Authors' conclusion
The HbA1c, when compared to the OGTT, showed high sensitivity and specificity in the diagnosis of prediabetes in young women with PCOS.
Study context
- Population
- Women aged 20–40 years with polycystic ovary syndrome (PCOS); excluded: diabetes, hyperprolactinemia, thyroid or adrenal diseases, anemia, users of hormonal contraception or corticosteroids
- Participants
- 154 women
- Exposure
- HbA1c vs oral glucose tolerance test (OGTT) for diagnosis of prediabetes and diabetes
- Outcome
- Diagnostic accuracy of HbA1c vs OGTT (gold standard)
Methodological detailsClinical, biochemical and US data from electronic medical records
- Clinical, biochemical and US data from electronic medical records
Main finding
As reported in the abstract
Kappa coefficient
0.41
95% CI 0.24–0.58
By group
HbA1c
- Specificity, prediabetes
- 89.5%
- Sensitivity, prediabetes
- 85.7%
- Specificity, diabetes
- 100%
- Sensitivity, diabetes
- 66.7%
HbA1c
Specificity, prediabetes89.5%
Sensitivity, prediabetes85.7%
Specificity, diabetes100%
Sensitivity, diabetes66.7%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Glycaemic classification | P > 0.05 |
- Glycaemic classification — Normal range, OGTT vs HbA1c
- 79.2% vs 76%
- Glycaemic classification — Prediabetes, OGTT vs HbA1c
- 16.8% vs 19.5%
- Glycaemic classification — Diabetes, OGTT vs HbA1c
- 4% vs 4.5%
Original publication
The role of glycated hemoglobin in the diagnosis of prediabetes and diabetes mellitus in young women with polycystic ovary syndrome. Clin Endocrinol (Oxf). Published 12 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →