Characterization of Turner Syndrome-associated Diabetes Mellitus
Authors' conclusion
In the spectrum of DM subtypes, TS-associated DM lies between type 1 and type 2 DM with features of both. Key factors include weight and IR. Assessing C-peptide or GAD antibodies may aid future insulin requirement.
Study context
- Population
- Adult women with Turner syndrome (TS) (age range, 18–70 years) undergoing annual health surveillance, University College Hospitals
- Participants
- 106 women
- Exposure
- Women with TS with vs without impaired glucose tolerance (IGT)
- Outcome
- Glucose tolerance, insulin, autoimmune and SNV profile; prevalence of DM
Methodological detailssingle-centre, 2 phases, tertiary referral center
- Single-centre
- 2 phases
- Tertiary referral center
Main finding
As reported in the abstract
Glucose tolerance on OGTT screening, among those without previous DM diagnosis
Observational data: associations, not effects.
Further findings
Diabetes mellitus (DM) risk markers in IGT or DM vs normal glucose tolerance
- Women with IGT or DM were older, with higher BMI and insulin resistance (IR)
- No association between autoimmune markers (glutamic acid decarboxylase (GAD), islet antigen-2, zinc transporter 8), risk karyotypes or selected single-nucleotide variation (SNVs) and DM
Insulin requirement in DM cases
- GAD positivity was associated with requirement for insulin therapy
Age at DM diagnosis
- Median age of onset of DM diagnosis
- 36 years (range, 11-56 years)
Original publication
Characterization of Turner Syndrome-associated Diabetes Mellitus. J Clin Endocrinol Metab. Published 4 July 2024. doi:10.
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