Serum Metabolomic Analysis of Healthy and Central Precocious Puberty Girls
Authors' conclusion
A total of 14 metabolites were identified through non-targeted metabolomics combined with four major metabolic network analyses. The above metabolites form a metabolic network that may serve as a novel marker and potential combined therapeutic target for the diagnosis of CPP.
Study context
- Population
- Girls with untreated central precocious puberty and healthy girls
- Participants
- 55 participants
- Comparison
- Girls with central precocious puberty (CPP) vs healthy controls
- CPPn = 30
- Healthy controlsn = 25reference
- Outcome
- Differential serum metabolites, CPP vs controls
Methodological detailsnon-targeted metabolomics
- Non-targeted metabolomics
Main finding
As reported in the abstract
Differential metabolites identified
1107
Upregulated
681
Downregulated
426
Metabolites identified via non-targeted metabolomics plus four major metabolic network analyses
14
Observational data: associations, not effects.
Original publication
Serum Metabolomic Analysis of Healthy and Central Precocious Puberty Girls. Clin Endocrinol (Oxf). Published 5 March 2025. doi:10.
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