Fiber Intervention Study in Prader-Willi Syndrome: Insights into Metabolic and Microbiota Shifts
Authors' conclusion
While this study did not observe significant changes in primary or secondary endpoints, it suggests that a short-term high-fiber intervention may induce beneficial shifts in gut microbiota and microbial metabolites in individuals with PWS. Further research is warranted to investigate the long-term effects and potential therapeutic applications of fiber interventions in PWS.
Study context
- Population
- Individuals with Prader-Willi syndrome; median age 13.6 years, 8 (57.1%) femalecrossover
- Participants
- 14 individuals
- Comparison
- High-dose fiber intervention vs control, 3 weeks each
- Outcome
- Hyperphagia and key metabolic markers
- Follow-up
- 3 weeks
Methodological detailswashout period of 4 to 8 weeks
- Washout period of 4 to 8 weeks
Main finding
As reported in the abstract
- Fiber did not significantly alter hyperphagia or key metabolic markers
- No significant changes in primary or secondary endpoints
Secondary outcomes
Gut microbiota
- Shifts in gut microbiota diversity; increased abundance of beneficial bacteria, e.g. Bifidobacterium longum and Faecalibacterium prausnitzii
Fecal and serum metabolites
- Altered fecal and serum metabolites, incl. decrease in branched-chain fatty acids and increase in serum C4-OH acylcarnitine
Safety
- Participants reported high tolerance to the fiber intervention
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Fiber Intervention Study in Prader-Willi Syndrome: Insights into Metabolic and Microbiota Shifts. J Clin Endocrinol Metab. Published 1 March 2025. doi:10.
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