Serum Luteinizing Hormone (LH) levels are associated to serum insulin and Anti‐Müllerian hormone levels in women with both functional hypothalamic amenorrhoea and polycystic ovarian morphology
Authors' conclusion
Our study suggests that GnRH insufficiency in women with PCOM unravels some mechanisms of LH regulation that are poorly documented in the literature and may involve a direct pituitary effect, as suggested by our results with serum insulin and AMH levels.
Study context
- Population
- Women with functional hypothalamic amenorrhoea defined by strict criteria, 2006–2020
- Participants
- 62 Functional Hypothalamic Amenorrhoea (FHA) patients
- Exposure
- FHA with Polycystic Ovarian Morphology (PCOM) vs FHA without PCOM
- Outcome
- Association of serum LH with BMI, serum insulin and/or AMH in women with FHA and PCOM
Main finding
As reported in the abstract
Correlates of serum LH
- PCOM+: LH positively correlated with fasting insulin
- p = .011
- PCOM+: LH positively correlated with Anti-Müllerian Hormone (AMH)
- p = .035
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| BMI, AMH and FSH, PCOM+ vs PCOM−PCOM+ vs PCOM− · higher with PCOM+ | P = 0.024 |
| BMI, AMH and FSH, PCOM+ vs PCOM−PCOM+ vs PCOM− · higher with PCOM+ | P = 0.0001 |
| BMI, AMH and FSH, PCOM+ vs PCOM−PCOM+ vs PCOM− · lower with PCOM+ | P = 0.002 |
Prevalence of PCOM in FHA
- FHA with PCOM
- Forty-two percentage
Original publication
Serum LH levels are associated to serum insulin and Anti‐Müllerian hormone levels in women with both functional hypothalamic amenorrhoea and polycystic ovarian morphology. Clin Endocrinol (Oxf). Published 16 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →