Reassessing the Luteinizing Hormone/Follicle‐Stimulating Hormone Ratio in Polycystic Ovary Syndrome: Associations With a Possible Neuroendocrine and Anti‐Müllerian Hormone‐Related Phenotype
Authors' conclusion
A high LH:FSH ratio is associated with a clinical and hormonal pattern-including elevated AMH levels, prominent PCOM, and anovulation-that may be consistent with a neuroendocrine-dominant presentation of PCOS, rather than metabolic or androgenic disturbances.
Study context
- Population
- Women with polycystic ovary syndrome (PCOS) by Rotterdam criteria at a tertiary university hospital
- Participants
- 316 women
- Exposure
- Luteinizing hormone (LH):Follicle-stimulating hormone (FSH) ratio >2 vs ≤2; PCOS phenotypes A, B, C, D
- Outcome
- Associations of LH:FSH ratio
Methodological detailsobservational, tertiary university hospital
- Observational
- Tertiary university hospital
Main finding
As reported in the abstract
- LH:FSH ratio >2
- 18.35%
- Correlation of LH:FSH ratio with anti-Müllerian hormone (AMH) (r)
- 0.65, p < 0.001
- Correlation with ovarian volume (r)
- 0.20, p = 0.001
- Mean LH:FSH with vs without PCOM
- 1.59 vs. 1.15, p < 0.001
- Phenotype D (OA + PCOM, non-hyperandrogenic) had the highest LH:FSH ratio
- 1.75 ± 0.87
- LH:FSH with vs without oligo/amenorrhea
- 1.59 vs. 1.22, p < 0.001
- LH:FSH with vs without anovulation
- 1.66 vs. 1.16, p < 0.001
- Correlation with midluteal progesterone (ρ)
- −0.28, p < 0.001
- Correlation with insulin (ρ)
- 0.18, p = 0.022
- Correlation with HOMA-IR (ρ)
- 0.18, p = 0.021
Observational data: associations, not effects.
Original publication
Reassessing the Luteinizing Hormone/Follicle‐Stimulating Hormone Ratio in Polycystic Ovary Syndrome: Associations With a Possible Neuroendocrine and Anti‐Müllerian Hormone‐Related Phenotype. Clin Endocrinol (Oxf). Published 23 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →