Serum adiponectin concentrations as a risk factor for cardiovascular complications in type 1 diabetes
Authors' conclusion
Adiponectin may protect carotid atherosclerosis and peripheral artery disease in T1D. It may be associated with increased cardiovascular events, depending on cardiac structural changes.
Study context
- Population
- Participants with T1D in DCCT/EDIC; adiponectin measured in EDIC year 8
- Participants
- 1,040 participants
- Exposure
- Adiponectin quartiles
- Outcome
- Peripheral artery disease (ankle brachial index)
Methodological detailsanalysis of DCCT/EDIC data, multivariable regression, Cox proportional hazards models
- Analysis of DCCT/EDIC data
- Multivariable regression
- Cox proportional hazards models
Main finding
As reported in the abstract
Odds ratio (95% CI)
Q4vs Q1
0.22(0.07–0.72)
Q3vs Q1
0.48(0.18–1.25)
Q2vs Q1
0.38(0.14–0.99)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Any cardiovascular eventsQ4vs Q1Associations diminished after adjustment for LVEDV index | 2.59 (1.10–6.06) | |
| Any cardiovascular eventsQ3vs Q1Associations diminished after adjustment for LVEDV index | 2.03 (0.90–4.59) | |
| Any cardiovascular eventsQ2vs Q1Associations diminished after adjustment for LVEDV index | 1.22 (0.52–2.85) | |
| Major atherosclerotic cardiovascular eventsQ4vs Q1Associations diminished after adjustment for LVEDV index | 11.37 (2.04–63.43) | |
| Major atherosclerotic cardiovascular eventsQ3vs Q1Associations diminished after adjustment for LVEDV index | 5.68 (1.04–31.07) | |
| Major atherosclerotic cardiovascular eventsQ2vs Q1Associations diminished after adjustment for LVEDV index | 3.76 (0.65–21.77) | |
| 0.050.21520Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Serum adiponectin concentrations as a risk factor for cardiovascular complications in type 1 diabetes. Diabetes Res Clin Pract. Published 10 May 2023. doi:10.
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