HbA1c Variability as an Independent Risk Factor for Microvascular Complications in Type 1 Diabetes
Authors' conclusion
Our results showed a significant independent association between HbA1c variability and the risk of microvascular complications in T1D. HbA1c variability might be a supplemental risk stratification tool to mean HbA1c for microvascular complications in T1D.
Study context
- Population
- Patients with T1D from the DCCT/EDIC data set
- Participants
- 1,240 patients
- Comparison
- HbA1c variability quartiles
- Primary endpoint
- Incident microvascular complications
- Follow-up
- Average of 20.5 years
Methodological detailsmultivariable models, HbA1c variability quartiles
- Multivariable models
- HbA1c variability quartiles
Primary result
As reported in the abstract
Incident microvascular complications (retinopathy, nephropathy, clinical neuropathy, autonomic neuropathy)
- HbA1c variability positively associated with higher risk of all diabetic microvascular complications, after adjusting for clinical risk factors
- P < .05
- Retinopathy: times higher odds (95% CI) with HbA1c variability
- 1.125 (1.082-1.170)
- Nephropathy: times higher odds (95% CI) with HbA1c variability
- 1.114 (1.074-1.154)
- Clinical neuropathy: times higher odds (95% CI) with HbA1c variability
- 1.061 (1.024-1.099)
- Autonomic neuropathy: times higher odds (95% CI) with HbA1c variability
- 1.088 (1.052-1.125)
Further findings
Incident microvascular complications by HbA1c variability, stratified by group median HbA1c 7.9%
- HbA1c above median: higher incident microvascular complications with higher HbA1c variability
- HbA1c below median: only higher incident autonomic neuropathy with higher HbA1c variability
Original publication
HbA1c Variability as an Independent Risk Factor for Microvascular Complications in Type 1 Diabetes. J Diabetes Sci Technol. Published 2 June 2022. doi:10.
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