Body-weight Cycling and Risk of Diabetic Kidney Disease in People With Type 1 Diabetes in the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Population
Authors' conclusion
Body-weight cycling is significantly associated with an increased risk of kidney events in people with type 1 diabetes, regardless of body mass index and traditional risk factors.
Study context
- Population
- People with T1D, DCCT/EDIC participants; body-weight variability over DCCT follow-up (6 ± 2 years)
- Participants
- 1,432 people
- Exposure
- Body-weight cycling
- Outcome
- Progression to CKD (six criteria) by VIM, the main index of body-weight variability
- Follow-up
- DCCT/EDIC (21 ± 4 years)
Methodological detailssecondary analysis of DCCT/EDIC data, Cox analyses
- Secondary analysis of DCCT/EDIC data
- Cox analyses
Main finding
As reported in the abstract
Renal events per 1 SD of VIM
40% decline in eGFR from baseline: HR, 95% CI 1.09-1.41, P = .001
1.25
Doubling of baseline serum creatinine: HR, 95% CI 1.13-1.57, P = .001
1.34
Chronic kidney disease (CKD) stage 3: HR, 95% CI 1.12-1.63, P = .002
1.36
Observational data: associations, not effects.
Further findings
Moderately and severely increased albuminuria
- Variability independent of the mean (VIM) associated with incidence, but not significant after adjustment for follow-up covariates
Other indices of body-weight cycling
- Similar results observed
Original publication
Body-weight Cycling and Risk of Diabetic Kidney Disease in People With Type 1 Diabetes in the DCCT/EDIC Population. J Clin Endocrinol Metab. Published 4 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →