Selenium levels and their association with thyroid autoimmunity and severe preeclampsia in pregnancy: Insights from a prospective ideal breast milk cohort study
Authors' conclusion
Pregnant women experience mild selenium deficiency, which can lead to significant health issues including maternal thyroid autoimmunity and obstetrical complications during pregnancy. Guidelines for appropriate selenium intake according to the stage of pregnancy and the number of fetuses are needed.
Study context
- Population
- South Korean pregnant women, Ideal Breast Milk (IBM) Cohort Study; measurements in second or third trimesterof 442 participants
- Participants
- 367 women
- Exposure
- Plasma selenium categories
- Deficientn = 30
- Suboptimaln = 164
- Outcome
- Plasma selenium
- Follow-up
- Second or third trimester
Main finding
As reported in the abstract
Median plasma selenium (range 46.7-206.4)
98.8 μg/L
Deficient
30
8%
Suboptimal
164
45%
Observational data: associations, not effects.
Further findings
Thyroid parenchymal heterogeneity on US — Deficient vs Suboptimal · across 3 groups · independently of gestational age
P = 0.042
| Outcome | Deficient | Suboptimal | Optimal | P value |
|---|---|---|---|---|
| Positive anti-TPO antibodyDeficient vs Optimal · independently of gestational age | 13.3% | — not stated in the abstract | 4.6% | P = 0.031 |
— not stated in the abstract
- Severe preeclampsia by selenium supplement use · Selenium supplement vs No supplement · lower with selenium supplement
- P = 0.015
- Severe preeclampsia by selenium supplement use — Severe preeclampsia, selenium supplement
- 0%
- Severe preeclampsia by selenium supplement use — Severe preeclampsia, no supplement
- 9.0%
Severe preeclampsia by selenium supplement use
- Higher without supplements, particularly in twin pregnancies
Original publication
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