Assessment of Cardiometabolic Risk Factors and Insulin Sensitivity by Hyperinsulinemic–Euglycemic Clamp in Resistance to Thyroid Hormone β Syndrome
Authors' conclusion
Using HEC as the gold standard method, no evidence of reduced insulin sensitivity in skeletal muscle was documented in RTHβ adult patients; however, higher levels of TC and LDL-C were observed in these patients
Study context
- Population
- Patients with resistance to thyroid hormone β (THRB mutations), adults and children, vs controls matched for age, sex and body mass index (BMI)
- Participants
- 16 vs 28
- Comparison
- Patients with RTHβ vs matched controls
- RTHβn = 16
- Controlsn = 28reference
- Outcome
- Cardiometabolic risk factors and insulin sensitivity (HEC in adults; HOMA-IR in all)
Methodological detailscontrols matched for age, sex and BMI
- Controls matched for age, sex and BMI
Main finding
As reported in the abstract
- Adult patients meeting criteria for metabolic syndrome
- 2
Observational data: associations, not effects.
Original publication
Assessment of Cardiometabolic Risk Factors and Insulin Sensitivity by Hyperinsulinemic–Euglycemic Clamp in Resistance to Thyroid Hormone β Syndrome. Thyroid. Published 3 July 2024. doi:10.
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