Longitudinal trajectories of maternal TSH in healthy pregnant women in Catalonia
Authors' conclusion
Three differentiated TSH trajectories were found in healthy pregnant women living in Catalonia, as previously described. No association with obstetric outcomes was observed in these different chronological thyroid pathways, but maternal age might condition the longitudinal mechanism of thyroid function regulation throughout pregnancy.
Study context
- Population
- Healthy pregnant women in Catalonia, followed from first trimester to delivery; thyroid function and autoimmunity measured in the three trimesters
- Participants
- 414 women
- Exposure
- TSH trajectory classes during pregnancy
- Outcome
- Longitudinal trajectories of maternal thyroid function (TSH) and their association with maternal-fetal outcomes
- Follow-up
- First trimester to delivery
Methodological detailslongitudinal, latent class growth analysis
- Longitudinal
- Latent class growth analysis
Main finding
As reported in the abstract
Maternal TSH trajectory classes
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Maternal characteristics among classesBetween Class 1 and Class 2 · differences among the three classes | P = 0.027 |
| Maternal characteristics among classesBetween Class 1 and Class 2 · differences among the three classes | P = 0.043 |
Free thyroxine levels
- No statistical differences among the three classes
Maternal characteristics among classes
- Maternal age correlated with trajectories in logistic regression, and independently of thyroid autoimmunity (TAI) status in multinomial logistic regression
Original publication
Longitudinal trajectories of maternal TSH in healthy pregnant women in Catalonia. Eur Thyroid J. Published 11 August 2023. doi:10.
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