Expansion of the immature B lymphocyte compartment in Graves' disease
Authors' conclusion
This study reports a robust association between KRECs and GD, highlighting the importance of B cells in the pathogenesis of GD and the influence of thyroid status on B cell activity. The findings indicate a potential role for KRECs as a marker of disease activity and outcome in GD.
Study context
- Population
- Patients with Graves' disease (GD) and healthy controls; flow cytometry of B cell subpopulations in 65 GD patients
- Participants
- 132 vs 140
- Comparison
- GD patients vs healthy controls
- GDn = 132
- Healthy controlsn = 140reference
- Outcome
- Circulating KRECs
Methodological detailsKRECs measured by quantitative real-time PCR with a triple-insert plasmid control, Flow cytometry on isolated CD19+ B cells to quantitate 7 B lymphocyte subpopulations
- KRECs measured by quantitative real-time PCR with a triple-insert plasmid control
- Flow cytometry on isolated CD19+ B cells to quantitate 7 B lymphocyte subpopulations
Main finding
As reported in the abstract
- GD vs Healthy controls: P = 1.5 × 10-9
Observational data: associations, not effects.
Further findings
Correlation of KRECs with thyroid hormones and autoantibodies in GD
- FT4: rho
- rho = .30, P = 2.14 × 10-5
- FT3: rho
- rho = .37, P = 1.99 × 10-7
- TRAb: rho
- rho = .23, P = 1.36 × 10-5
Higher KRECs 6-10 weeks after antithyroid drug (ATD) withdrawal and relapse of hyperthyroidism · 1 year
- Higher KRECs associated with relapse of hyperthyroidism at 1 year
- P = 0.04
Correlation of KRECs with total CD19+ B cell count
- Positive correlation
- P = 3.2 × 10-7
Original publication
Expansion of the immature B lymphocyte compartment in Graves' disease. Eur J Endocrinol. Published 3 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →