Role of Hepatic Glycogen on Nocturnal Gluconeogenesis in Type 2 Diabetes Mellitus
Authors' conclusion
Selective targeting of GNG at night with appropriate medications could reduce nocturnal and early morning fasting hyperglycemia and hepatic insulin resistance in people with T2D.
Study context
- Population
- 14 subjects with T2D and 15 matched subjects with no diabetes (ND), studied overnight14 T2D, 15 ND
- Comparison
- Glycogen loading vs nonglycogen loading isocaloric meals for 3 days
- Outcome
- Contribution of GNG to nocturnal EGP
- Follow-up
- Overnight
Methodological detailsrandomised order, crossover, matched controls, isotope tracer, 13C magnetic resonance spectroscopy (MRS)
- Randomised order
- Crossover
- Matched controls
- Isotope tracer
- 13C MRS
Main finding
As reported in the abstract
Hepatic glycogen, nocturnal EGP and % GNG to EGP
% GNG to endogenous glucose production (EGP) in ND throughout the night after both meals
∼50%
Original publication
Role of Hepatic Glycogen on Nocturnal Gluconeogenesis in Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. Published 4 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →