Beneficial Effects of Carbohydrate Restriction in Type 2 Diabetes Can Be Traced to Changes in Hepatic Metabolism
Primary resultResult — go to the resultDifference in liver fat 28%Authors' conclusion
A shift in hepatic metabolism to favor fat oxidation over DNL may underlie the beneficial effects of carbohydrate restriction on hepatic steatosis and glucose-induced insulin secretion.
Study context
- Population
- Adults with mild T2D
- Participants
- 57 adults
- Comparison
- Eucaloric ketogenic diet vs eucaloric low-fat diet
Primary result
As reported in the abstract
week 12
Difference in liver fat
28%
P < 0.05
- Pyruvate change with ketogenic diet (KD)
- −23%, P < .001
- Palmitoleic acid (de novo lipogenesis (DNL) marker) change with KD
- −32%, P < .01
Further findings
| Outcome | Difference | P value |
|---|---|---|
| Fasting glucagon · week 12 | 25% | P < 0.05 |
Correlates of change in liver fat (all combined)
- Change in pyruvate
- r = 0.45, P = .05
- Change in glucagon
- r = −0.34, P < .05
- Change in glucagon to C-peptide ratio
- r = −0.44, P < .01
- Change in ACP
- r = −0.34, P < .05
Change in ACP vs change in pyruvate
- KD
- r = −0.5, P < .05
- Low-fat diet (LFD): not associated
Original publication
Beneficial Effects of Carbohydrate Restriction in Type 2 Diabetes Can Be Traced to Changes in Hepatic Metabolism. J Clin Endocrinol Metab. Published 31 May 2025. doi:10.
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