Effects of a Carbohydrate-Restricted Diet on β-Cell Response in Adults With Type 2 Diabetes
Authors' conclusion
These results suggest that a eucaloric CR diet has beneficial effects on β-cell function in patients with mild T2D.
Study context
- Population
- African American and European American adults with T2D not using insulin; medications discontinued 1 to 2 weeks before baseline
- Participants
- 57 participants
- Comparison
- Eucaloric carbohydrate-restricted (CR) diet vs eucaloric higher carbohydrate (HC) diet
- Primary endpoint
- β-cell response to glucose: acute (first-phase) and maximal (arginine-stimulated) C-peptide response by hyperglycemic clamp
- Follow-up
- 12 weeks
Methodological detailseucaloric, controlled diet therapy (all food provided)
- Eucaloric
- Controlled diet therapy (all food provided)
Primary result
As reported in the abstract
Acute C-peptide response
- Significant effect of diet; 2-fold greater with CR diet
- P < .01
Further findings
Maximal C-peptide response · 12 weeks
- Significant effect of diet; 22% greater with CR diet
- P < 0.05
- Significant diet-by-race interaction
- P < 0.05
- European Americans: 48% greater with CR diet
- P < 0.01
Disposition index (oral glucose tolerance test (OGTT)) · 12 weeks
- Significant effect of diet; 32% greater with CR diet
- P < 0.05
Original publication
Effects of a Carbohydrate-Restricted Diet on β-Cell Response in Adults With Type 2 Diabetes. J Clin Endocrinol Metab. Published 22 October 2024. doi:10.
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