Risk of Infection in Older Adults With Type 2 Diabetes With Relaxed Glycemic Control
Authors' conclusion
Older patients with type 2 diabetes who achieve relaxed glycemic control levels endorsed by clinical guidelines are not at significantly increased risk of hospitalization for most infections, but HbA1c 8% to <9% is associated with an increased risk of hospitalization for skin, soft tissue, and bone infections.
Study context
- Population
- Adults aged ≥65 years with T2D from an integrated health care delivery system, 1 January 2019 to 1 March 2020
- Participants
- 103,242 adults
- Exposure
- Relaxed glycaemic control vs intensive
- Outcome
- Hospitalization for infections (respiratory; genitourinary; skin, soft tissue, and bone; and sepsis)
Methodological detailsintegrated health care delivery system, Negative binomial models used to estimate incidence rates and RR
- Integrated health care delivery system
- Negative binomial models used to estimate incidence rates and RR
Main finding
As reported in the abstract
Hospitalization for infections
Each group vs HbA1c 6% to <7%Relative risk (95% CI)
HbA1c 8% to <9%
1.25(1.13–1.39)
HbA1c 7% to <8%
0.99(0.91–1.08)
- Overall rate of hospitalization for infections
- 51.3 per 1,000 person-years
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted RR (95% CI) | |
|---|---|---|
| Hospitalization for skin, soft tissue, and bone infectionHbA1c 8% to <9%vs HbA1c 6% to <7% | 1.33 (1.05–1.69) | |
| 0.512Adjusted relative risk (log scale) |
Hospitalization for skin, soft tissue, and bone infection
- Adjusted RR significantly higher with HbA1c 8% to <9% only for skin, soft tissue, and bone infection across infection categories
Original publication
Risk of Infection in Older Adults With Type 2 Diabetes With Relaxed Glycemic Control. Diabetes Care. Published 22 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →