Pancreatic fat infiltration is associated with risk of vertebral fracture in older patients with type 2 diabetes: A longitudinal multicenter study
Authors' conclusion
Pancreatic fat infiltration is an associated factor for vertebral fracture in T2DM patients. Addition of pancreatic fat infiltration improved the predictive performance of the bone-based model.
Study context
- Population
- T2D patients aged ≥50 years without preexisting vertebral fractures, 2019–2023, followed until January 2024
- Participants
- 1,486 patients
- Exposure
- Pancreatic computed tomography (CT) attenuation and P/S ratio vs risk of vertebral fracture
- Vertebral fracturen = 135
- No vertebral fracturen = 270reference
- Outcome
- Vertebral fracture on spine CT (Genant's semiquantitative scoring)
- Follow-up
- 26 months
Methodological detailsmatched cases and controls
- Matched cases and controls
Main finding
As reported in the abstract
26 months
Pancreatic CT attenuation, aHR
0.97
95% CI 0.96–0.99
P/S ratio, aHR
0.26
95% CI 0.12–0.58
Observational data: associations, not effects.
Further findings
Predictive performance: bone attenuation-based model with vs without pancreatic attenuation or P/S ratio
- AUC with pancreatic attenuation or P/S ratio added
- 0.72-0.763
- AUC bone attenuation-based model
- 0.63-0.728
Original publication
Pancreatic fat infiltration is associated with risk of vertebral fracture in older patients with type 2 diabetes: A longitudinal multicenter study. Diabetes Res Clin Pract. Published 22 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →