Impact of bariatric surgery on glycaemic and metabolic outcomes in people with obesity and type 2 diabetes mellitus: A meta‐analysis
Authors' conclusion
Bariatric surgery significantly improves glycaemic and metabolic outcomes in obese patients with T2DM. These findings support its integration into diabetes management pathways, offering a promising approach for long-term disease control and complication reduction. Further research is needed to evaluate long-term outcomes and mechanisms.
Study context
- Population
- People with obesity and T2D; PubMed, Scopus, EMBASE and Web of Science searched from inception to March 2025
- Participants
- 3,855 people39 studies
- Comparison
- Bariatric surgery in people with obesity and T2D
- Outcome
- Glycaemic and metabolic outcomes: FBG, PPG, HbA1c, C-peptide, HOMA-IR and fasting insulin
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
Bariatric surgeryWMD (95% CI)P value
FBG; significant reduction
3.461(2.740–4.182)
P < 0.001PPG; significant reduction
6.153(4.298–8.007)
P < 0.001HbA1c; significant reduction
2.085(1.561–2.608)
P < 0.001- C-peptide: modest but non-significant improvement
- 0.358 (SMD; 95% CI −0.043 to 0.759; p = 0.075)
- Fasting insulin: modest but non-significant improvement
- 1.593 (SMD; 95% CI −0.392 to 3.577; p = 0.104)
- HOMA-IR: significant reduction
- 2.480 (weighted mean differences (WMD); 95% CI 1.010-3.950; p = 0.009)
Original publication
Impact of bariatric surgery on glycaemic and metabolic outcomes in people with obesity and type 2 diabetes mellitus: A meta‐analysis. Diabetes Obes Metab. Published 23 May 2025. doi:10.
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