Proinsulin–to–C-Peptide Ratio as a Marker of β-Cell Function in African American and European American Adults
Authors' conclusion
The PI-to-CP ratio could be useful in identifying African American individuals at highest risk for β-cell dysfunction and ultimately type 2 diabetes.
Study context
- Population
- African American and European American adult men and women without T2D
- Participants
- 114 participants
- Exposure
- African American vs European American adults
- Outcome
- PI-to-CP ratio as an index of proinsulin secretion, and its association with indices of β-cell function
Methodological details2-h OGTT; Matsuda index for insulin sensitivity; Disposition index (DI) per phase of β-cell response; Pearson correlations; multiple linear regression for race, BMI and glucose tolerance status, before and after adjustment for insulin sensitivity
- 2-h OGTT; Matsuda index for insulin sensitivity; DI per phase of β-cell response; Pearson correlations; multiple linear regression for race, BMI and glucose tolerance status, before and after adjustment for insulin sensitivity
Main finding
As reported in the abstract
PI-to-CP ratio · fasting and 2-h OGTT
- African American participants had higher fasting and 2-h proinsulin-to-C-peptide (PI-to-CP) ratios
- Fasting PI-to-CP ratio positively associated with Φb
- Fasting and 2-h PI-to-CP ratios inversely associated with disposition indices (DId) and insulin sensitivity only in African American participants
Observational data: associations, not effects.
Original publication
Proinsulin–to–C-Peptide Ratio as a Marker of β-Cell Function in African American and European American Adults. Diabetes Care. Published 14 February 2023. doi:10.
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