Lp(a) concentration and polymorphic size are not associated with new onset diabetes in individuals with prediabetes
Authors' conclusion
In a high-risk population, Lp(a) concentration or polymorphic size do not appear to be substantially associated with type 2 diabetes risk.
Study context
- Population
- Individuals with prediabetes (impaired fasting glucose, FPG 110–125 mg/dl), IT-DIAB study, followed annually for 5 years
- Participants
- 303 individuals
- Exposure
- New-onset diabetes (NOD) vs no NOD concentration and Kringle-IV (K-IV) repeat number)
- NODn = 113
- Outcome
- Development of NOD, defined as a first FPG ≥ 126 mg/dl during follow-up
- Follow-up
- 5 years
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
Developed NOD during follow-up
113
37%
Observational data: associations, not effects.
Further findings
Non-detectable Lp(a) (≤ 7 nmol/l)
P = 0.46
Elevated Lp(a) (>125 nmol/l)
P > 0.99
Original publication
Lp(a) concentration and polymorphic size are not associated with new onset diabetes in individuals with prediabetes. Diabetes Metab. Published 3 February 2025. doi:10.
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