Type 2 & other diabetes

Dietary profiles and associated metabolic risk factors in India from the ICMR–INDIAB survey-21

Nat MedPublished Cross-sectional study

Study context

Population
Adults in India, national ICMR–INDIAB survey
Participants
18,090 adults
Exposure
Highest vs lowest carbohydrate intake; isocaloric substitution of carbohydrates with other macronutrients
Outcome
Metabolic risk, highest vs least carbohydrate intake
Methodological detailsnational survey
  • National survey

Main finding

As reported in the abstract

Each group vs least carbohydrate intakeEstimate (95% CI)
Highest carbohydrate intake
OR, newly diagnosed T2D 1.30(1.14,1.47)
Highest carbohydrate intake
OR, prediabetes 1.20(1.06,1.33)
Highest carbohydrate intake
OR, generalized obesity 1.22(1.07,1.37)
Highest carbohydrate intake
OR, abdominal obesity 1.15(1.01–1.30)

Observational data: associations, not effects.

Further findings

Replacing refined cereals with whole wheat or millet flour without decreasing overall carbohydrate quantity

OR, T2D (not associated with lower risk)
0.94 (95% CI 0.57, 1.56)
OR, abdominal obesity (not associated with lower risk)
1.08 (95% CI 0.66, 1.76)

Modeled isocaloric substitution of carbohydrates for plant, dairy, egg or fish protein

OR, T2D, dairy
0.89 (95% CI 0.83, 0.95)
OR, T2D, egg
0.91 (95% CI 0.82, 0.99)
OR, prediabetes, dairy
0.82 (95% CI 0.72, 0.92)
OR, prediabetes, fish
0.94 (95% CI 0.89, 0.99)
  • Ranges across protein sources as printed

Original publication

Dietary profiles and associated metabolic risk factors in India from the ICMR–INDIAB survey-21. Nat Med. Published 30 September 2025. doi:10.1038/s41591-025-03949-4

Composed by AI from the published abstract and checked against it. How Briefs are made →

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