Risk of type 2 diabetes and long-term antibiotic use in childhood: Evidence from the UK Biobank
Authors' conclusion
Long-term use of antibiotics in childhood is associated with the risk of T2DM in middle and old age in the UK Biobank population.
Study context
- Population
- UK Biobank participants who completed the online survey for digestive healthfinal analyses
- Participants
- 152,992 participants
- Exposure
- Long-term childhood antibiotic use vs no long-term use
- Exposedn = 22,133
- Outcome
- Incident T2D
Methodological detailsUK Biobank, Cox regression adjusted for sociodemographic, general health, mental health, lifestyle factors, comorbidities and medication use
- UK Biobank
- Cox regression adjusted for sociodemographic, general health, mental health, lifestyle factors, comorbidities and medication use
Main finding
As reported in the abstract
follow-up
Hazard ratio
1.16
95 % CI 1.07–1.27
Events by group
Exposed
681
events
Non-exposed
3370
events
Between Exposed and Non-exposed
HR 1.16 (95 % CI 1.07–1.27)
Observational data: associations, not effects.
Further findings
Subgroup and sensitivity analyses
- Results highly consistent with the primary analyses
Original publication
Risk of type 2 diabetes and long-term antibiotic use in childhood: Evidence from the UK Biobank. Diabetes Res Clin Pract. Published 9 February 2024. doi:10.
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