Epidemiology of heart failure in diabetes: a disease in disguise
Authors' conclusion
The systematic section of this review provides new insights on the prevalence/incidence of HF in type 2 diabetes, unveiling a large pre-clinical target group with LVDD/HFpEF in which disease progression could be halted by early recognition and treatment.
Study context
- Population
- Adults ≥18 years with T2D; studies reporting prevalence and incidence of heart failure (HF) subtypes using echocardiographic data (Embase, MEDLINE)57 + 29 studies
- Outcome
- Prevalence and incidence of HF subtypes (LVDD, HFpEF, LVSD, HFrEF, HFmrEF)
Methodological detailsrandom-effects meta-analysis, updated systematic review (2016-October 2022), echocardiographic data, 5015 studies found; 209 screened using full text, Evidence limited by heterogeneity of diagnostic criteria over the years
- Random-effects meta-analysis
- Updated systematic review (2016-October 2022)
- Echocardiographic data
- 5015 studies found; 209 screened using full text
- Evidence limited by heterogeneity of diagnostic criteria over the years
Pooled result
As reported in the abstract
Pooled prevalence of HF subtypes in T2D
- Prevalence of left ventricular diastolic dysfunction (LVDD) (n=65 studies, 25,729 individuals)
- 43% (95% CI 37%, 50%)
- Prevalence of HFpEF (n=8 studies, 5292 individuals)
- 17% (95% CI 7%, 35%)
- Prevalence of left ventricular systolic dysfunction (LVSD) (n=25 studies, 24,460 individuals)
- 6% (95% CI 3%, 10%)
- Prevalence of HF with reduced ejection fraction (HFrEF) (n=4 studies, 4090 individuals)
- 7% (95% CI 3%, 15%)
- Prevalence of HF with mildly reduced ejection fraction (HFmrEF) (n=2 studies, 2442 individuals)
- 12% (95% CI 7%, 22%)
Further pooled results
HF incidence (n=7 studies, 17,935 individuals)
- Incidence rate of HFpEF
- 7% [95% CI 4%, 11%]
- Incidence rate of HFrEF
- 4% [95% CI 3%, 7%]
- Higher incidence rate of HFpEF than HFrEF
Original publication
Epidemiology of heart failure in diabetes: a disease in disguise. Diabetologia. Published 9 February 2024. doi:10.
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