Risk analysis of the association between different hemoglobin glycation index and poor prognosis in critical patients with coronary heart disease-A study based on the MIMIC-IV database
Authors' conclusion
There was a significant correlation between HGI and all-cause mortality in patients with critical coronary artery disease, particularly in those with low HGI. HGI can be used as a potential indicator for assessing the short- and long-term risk of mortality in such patients.
Study context
- Population
- Critical patients with coronary artery disease, MIMIC-IV database
- Participants
- 5,260 patients
- Exposure
- Hemoglobin glycation index (HGI) quartiles
- Outcome
- All-cause mortality
- Follow-up
- 30 days and 365 days
Methodological detailsMIMIC-IV database, HGI quartiles, Cox proportional hazards model, restricted cubic spline
- MIMIC-IV database
- HGI quartiles
- Cox proportional hazards model
- Restricted cubic spline
Main finding
As reported in the abstract
Each group vs Q2Hazard ratio (95% CI)P value
Low HGI30-day mortality; fully adjusted Cox model
1.96(1.38–2.78)
P < 0.001Low HGI365-day mortality; fully adjusted Cox model
1.48(1.19–1.85)
P < 0.001High HGI365-day mortality
1.31(1.02–1.69)
P < 0.05- 30-day mortality rate, overall
- 4.94%
- 365-day mortality rate, overall
- 13.12%
Observational data: associations, not effects.
Further findings
Stratified analysis
- Interaction test: correlation between HGI and outcome events remained stable
Original publication
Risk analysis of the association between different hemoglobin glycation index and poor prognosis in critical patients with coronary heart disease-A study based on the MIMIC-IV database. Cardiovasc Diabetol. Published 30 March 2024. doi:10.
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