Hemoglobin glycation index and rapid kidney function decline in diabetes patients: Insights from CHARLS
Authors' conclusion
Higher HGI may be associated with an increased risk of RKFD in diabetic patients.
Study context
- Population
- Patients with diabetes (CHARLS); Hemoglobin glycation index (HGI) = measured HbA1c minus predicted HbA1c
- Exposure
- Medium and higher HGI vs lower HGI
- Outcome
- Rapid kidney function decline (RKFD): 30 % decline in eGFR during follow-up
- Follow-up
- Median 4.0 years
Methodological detailsdirected acyclic graph, multivariate Cox proportional hazards models
- Directed acyclic graph
- Multivariate Cox proportional hazards models
Main finding
As reported in the abstract
RKFD
Each group vs lower HGIHazard ratio (95 % CI)
Medium HGI
1.75(0.72–4.25)
Higher HGI
2.64(1.12–6.21)
- RKFD occurred overall
- 43 patients (6.3 %)
- Linear association of HGI with RKFD
- Pfor nonlinear = 0.383
Observational data: associations, not effects.
Further findings
- Magnitude of associations not materially altered in all sensitivity analyses, but none significant
Original publication
Hemoglobin glycation index and rapid kidney function decline in diabetes patients: Insights from CHARLS. Diabetes Res Clin Pract. Published 21 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →