The Association of High and Low Glycation With Incident Diabetic Retinopathy in Adults With Type 1 Diabetes
Main finding · Incident DRResult — go to the resultOdds ratio 1.31 95% CI 0.48–3.62Authors' conclusion
The risk of diabetic retinopathy was not found to differ significantly comparing high glycators to low glycators in adults with T1D. Moreover, HbA1c - eA1c relationship was not stable in nearly 30% to 50% adults with T1D, suggesting that discordance in HbA1c and eA1c are mostly related either HbA1c measurements or estimation of A1c from sensor glucose rather than physiological reasons.
Study context
- Population
- Adults with T1D with HbA1c and continuous glucose monitoring (CGM) data up to 7 years before the eye examination defining incident diabetic retinopathy (DR) or no retinopathy
- Participants
- 119 adults
- Exposure
- High glycators vs low glycators
- High glycatorn = 36
- Low glycatorn = 49reference
- Unstable glycatorn = 34
- Outcome
- Incident DR
Main finding
As reported in the abstract
Odds ratio
1.31
95% CI 0.48–3.62
P = 0.15
High glycatorvs Low glycator
OR 1.31 (95% CI 0.48–3.62); P = 0.15
Observational data: associations, not effects.
Further findings
Unstable glycator with alternate criteria (HbA1c - eA1c > 0.4% or <0.4%)
- Adults characterized as unstable glycator
- 53%
Original publication
The Association of High and Low Glycation With Incident Diabetic Retinopathy in Adults With Type 1 Diabetes. J Diabetes Sci Technol. Published 28 May 2024. doi:10.
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