Sex-specific trends in incidence of first myocardial infarction among people with and without diabetes between 1985 and 2016 in a German region
Authors' conclusion
Over the study period, we found a decreased incidence of first MI and fatal MI in the entire study population. The initial increase of first non-fatal MI in men with diabetes needs further research. The gap between populations with and without diabetes remained.
Study context
- Population
- People with first myocardial infarction (MI) (non-fatal and fatal), KORA MI registry, Augsburg, Germany, 1985–2016; 34% fatal MI, 71% men, 30% with diabetespeople with first MI
- Participants
- 19,683 people
- Exposure
- People with diabetes vs without diabetes
- Outcome
- Sex-specific age-adjusted IR of first MI (non-fatal and fatal), and time trends
- Follow-up
- 1985 to 2016
Methodological detailsKORA myocardial infarction registry, Poisson regression, age-adjusted
- KORA myocardial infarction registry
- Poisson regression
- Age-adjusted
Main finding
As reported in the abstract
IR of first MI, entire study population
- Incidence rates (IR) of first MI decreased from
- 359 (per 100,000 person years; 95% CI: 345-374)
- IR of first MI decreased to (per 100,000 person years; 226-245)
- 236
- RR of first MI (diabetes vs no diabetes), men, 1985-1988 (1.22-1.61)
- 1.40
- RR of first MI, men, 1997-2000 (2.26-2.99)
- 2.60
- RR of first MI, men, 2013-2016 (1.47-2.09)
- 1.75
Observational data: associations, not effects.
Further findings
First MI and first non-fatal MI in men with diabetes
- In men with diabetes, IR of first MI decreased only in 2013-2016; IR of first non-fatal MI increased until 2009-2012 and slightly decreased in 2013-2016
Fatal vs first non-fatal MI
- Fatal MI declined stronger than first non-fatal MI; RR time trends similar for first non-fatal MI and fatal MI
Original publication
Sex-specific trends in incidence of first myocardial infarction among people with and without diabetes between 1985 and 2016 in a German region. Cardiovasc Diabetol. Published 30 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →