Lipidome characterisation and sex-specific differences in type 1 and type 2 diabetes mellitus
Authors' conclusion
Our findings revealed an extensive disruption of lipid metabolism in both T1D and T2D. Additionally, we found sex-specific lipidome changes associated with diabetes, and lipids associated with the glycaemic state that can be linked to previously described molecular mechanisms in diabetes.
Study context
- Population
- Subjects with T1D, T2D, prediabetes and controls without cardiovascular and/or chronic kidney disease
- Participants
- 360 subjects
- Exposure
- T1D vs T2D vs prediabetes vs controls
- T1Dn = 91
- T2Dn = 91
- Prediabetesn = 74
- Controls (CT)n = 104reference
- Outcome
- Lipidome alterations in T1D and T2D
Methodological detailsuntargeted lipidomic analysis, UHPLC-ESI-MS in positive and negative ion modes, multiple linear regression models
- Untargeted lipidomic analysis
- UHPLC-ESI-MS in positive and negative ion modes
- Multiple linear regression models
Main finding
As reported in the abstract
- Unique lipid subspecies annotated from 15 unique lipid classes
- 54
Observational data: associations, not effects.
Further findings
Sex-specific differences
- Ceramides and phosphatidylcholines exhibited important diabetes-associated differences due to sex
Glycaemic state
- Gradual increase of a panel of 1-deoxyceramides from normoglycemia to prediabetes to T2D
Original publication
Lipidome characterisation and sex-specific differences in type 1 and type 2 diabetes mellitus. Cardiovasc Diabetol. Published 29 March 2024. doi:10.
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