Retinopathy as an independent predictor of all-cause mortality in individuals with type 2 diabetes
Authors' conclusion
In patients with type 2 diabetes mellitus, the excess mortality risk conferred by DR is relatively small and higher in those without DKD and CVD, suggesting that it may be mediated by the concurrent presence of these complications, even at a subclinical level.
Study context
- Population
- Individuals with T2D, 19 Italian centres, enrolled 2006–2008mortality for 15,656
- Participants
- 15,773 individuals
- Exposure
- Any diabetic retinopathy (DR), advanced DR or proliferative DR vs no DR
- Outcome
- All-cause mortality
- Follow-up
- 31 October 2015
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
All-cause mortality (adjusted)
Each group vs no DRHazard ratio (95% CI)P value
Any DR
1.136(1.054–1.224)
P < 0.0001Advanced DR
1.213(1.097–1.340)
P < 0.0001Proliferative DR
1.381(1.207–1.580)
P < 0.0001Observational data: associations, not effects.
Further findings
DR impact by DKD/cardiovascular disease (CVD) status
- Impact of DR more evident in patients without than with DKD or CVD
- Mortality risk increased with DR alone, much less than with DKD or CVD alone, and particularly with both DR and DKD or CVD
- DR grade related to mortality without DKD or CVD; no additional risk with albuminuric or nonalbuminuric DKD or established CVD
Original publication
Retinopathy as an independent predictor of all-cause mortality in individuals with type 2 diabetes. Diabetes Metab. Published 29 November 2022. doi:10.
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