Elevation of hemoglobin A1c increases the risk of decline in left ventricular systolic function among patients with coronary artery disease
Authors' conclusion
Elevated HbA1c is a predictor of decline in LV systolic function in CAD patients. Clinicians should be aware of the risk of decline in LV systolic function in CAD patients with elevated HbA1c, and take measures as soon as possible.
Study context
- Population
- Patients with coronary artery disease (CAD); age 62.9 ± 10.6 years; 22.2% female
- Participants
- 3,994 patients
- Exposure
- HbA1c quartile groups
- Outcome
- Decline in LV systolic function: absolute decrease in LV ejection fraction (LVEF) ≥10% from baseline to follow-up
- Follow-up
- 3-12 months
Methodological detailsCardiorenal ImprovemeNt II (CIN-II) registry
- CIN-II registry
Main finding
As reported in the abstract
Decline in LV systolic function
Each group vs Q1Odds ratio (CI)P value
Q2
1.22(0.88–1.68)
P = 0.235Q3
1.48(1.07–2.05)
P = 0.019Q4
1.60(1.160–2.22)
P = 0.004- HbA1c (continuous) associated with decline in left ventricular (LV) systolic function, fully adjusted OR
- OR 1.12 [95%CI 1.05-1.20] P = 0.001
- Decline in LV systolic function during follow-up (all patients)
- 429 (11%)
Observational data: associations, not effects.
Further findings
- Patients with decline in LV systolic function had a higher risk of cardiovascular death
Original publication
Elevation of hemoglobin A1c increases the risk of decline in left ventricular systolic function among patients with coronary artery disease. Diabetes Metab. Published 15 November 2022. doi:10.
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