Different associations of atherogenic index of plasma, triglyceride glucose index, and hemoglobin A1C levels with the risk of coronary artery calcification progression according to established diabetes
Authors' conclusion
The associations between AIP, TyG index, and HbA1C levels with CAC progression vary according to established diabetes. Of these biomarkers, TyG index is independently associated with CAC progression irrespective of established diabetes.
Study context
- Population
- Asymptomatic Korean adults (mean age 51.7 ± 8.5 years; 84.2% males; 15.8% with diabetes)
- Participants
- 12,326 adults
- Exposure
- Diabetics vs non-diabetics; associations of atherogenic index of plasma (AIP), triglyceride glucose (TyG) index and HbA1c with coronary artery calcification (CAC) progression
- Outcome
- CAC progression: difference of ≥ 2.5 between square roots of baseline and follow-up CAC scores (SQRT method)
- Follow-up
- Median 3.0 years
Main finding
As reported in the abstract
Association of biomarkers with CAC progression (adjusted OR)
- AIP (per-0.1 unit increase), non-diabetics: OR 1.04, 95% CI 1.02 - 1.06
- P < 0.001
- HbA1c (per-1% increase), diabetics: OR 1.19, 95% CI 1.08 - 1.32
- P = 0.001
- TyG index (per-1 unit increase), non-diabetics: OR 1.32, 95% CI 1.19 - 1.46
- P < 0.001
- TyG index (per-1 unit increase), diabetics: OR 1.33, 95% CI 1.10 - 1.60
- P = 0.003
Observational data: associations, not effects.
Further findings
CAC progression frequency
AIP, TyG index and HbA1c levels · baseline
- Significantly higher in diabetics than in non-diabetics
Original publication
Different associations of atherogenic index of plasma, triglyceride glucose index, and hemoglobin A1C levels with the risk of coronary artery calcification progression according to established diabetes. Cardiovasc Diabetol. Published 19 November 2024. doi:10.
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