Prognostic impact of switching to the 2021 chronic kidney disease epidemiology collaboration creatinine-based equation in Caucasian patients with type 2 diabetes: the Renal Insufficiency and Cardiovascular events (RIACE) Italian Multicenter Study
Study context
- Population
- Caucasian patients with T2D, 19 Italian centres, enrolled 2006–2008vital status for 15,656
- Participants
- 15,773 patients
- Exposure
- 2021 vs 2009 CKD-EPI creatinine-based equation
- Outcome
- eGFR with 2021 vs 2009 CKD-EPI equation
- Follow-up
- Baseline
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Estimated glomerular filtration rate (eGFR) increased in all patients with the 2021 equation, except those with a 2009 eGFR ≥105
293 individuals
Reduced eGFR, 2009 to 2021 equation (reclassification)
17.28 to 13.96%
Any Chronic Kidney Disease (CKD), 2009 to 2021 equation (reclassification)
36.23 to 34.03%
Observational data: associations, not effects.
Further findings
Risk of death (vs 2009 G1) in reclassified vs non-reclassified · to 31 October 2015
- Lower risk of death for reclassified than non-reclassified in all eGFR categories; significant only in G4-G5
- ROC curves statistically, but not clinically different with the two equations
Profile of reclassified individuals · baseline
- Reclassified had better cardiometabolic risk profile, lower prevalence of complications and medication use
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prognostic impact of switching to the 2021 chronic kidney disease epidemiology collaboration creatinine-based equation in Caucasian patients with type 2 diabetes: the Renal Insufficiency and Cardiovascular events (RIACE) Italian Multicenter Study. Cardiovasc Diabetol. Published 24 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →