The associations between functional vitamin K status and all‐cause mortality, cardiovascular disease and end‐stage kidney disease in persons with type 1 diabetes
Authors' conclusion
In persons with type 1 diabetes, lower vitamin K status was associated with higher mortality, CVD and progression to ESKD, however, not after adjustment for other risk factors. Interventional studies are needed to elucidate the role of vitamin K in persons with type 1 diabetes.
Study context
- Population
- Persons with T1D; stored baseline samples (baseline visit 2009–2011)
- Participants
- 667 persons
- Exposure
- Per doubling of plasma dephosphorylated-uncarboxylated matrix Gla protein (dp-ucMGP)
- Outcome
- All-cause mortality per one doubling of dp-ucMGP
Main finding
As reported in the abstract
All-cause mortality per doubling of dp-ucMGP
Deaths during follow-up
53
HR, unadjusted model
2.06
95% CI 1.22–3.45
HR, fully adjusted model
0.88
95% CI 0.44–1.73
Observational data: associations, not effects.
Further findings
Incident cardiovascular disease (CVD) per doubling of dp-ucMGP
- HR, unadjusted model
- 1.58 (95% CI 1.03-2.42)
- Fully adjusted model: HR statistically insignificant
End-stage kidney disease (ESKD) per doubling of dp-ucMGP
- HR, unadjusted model
- 7.62 (95% CI 4.25-13.68)
- Fully adjusted model: HR statistically insignificant
Original publication
The associations between functional vitamin K status and all‐cause mortality, cardiovascular disease and end‐stage kidney disease in persons with type 1 diabetes. Diabetes Obes Metab. Published 21 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →