Trial of a Trivial Quantitative Heat-Pain Stimulus for Detecting Severe Loss of Nociception
Authors' conclusion
Due to its high specificity, the test seems advantageous for diagnostic purposes, complementary to current screening tests.
Study context
- Population
- Persons with DM with or without diabetic neuropathy and patients with a history of painless diabetic foot ulceration (DFU)
- Participants
- 72 persons
- Comparison
- 51°C heat-pain stimulus vs history of painless DFU
- Without neuropathyn = 30
- With neuropathyn = 12
- DFUn = 30reference
- Outcome
- Detection of DFU-related LON by pain intensity (0–10 numerical rating scale) to a six-second, 51°C heat-pain stimulus on a 38.5-mm² spot at the foot
Methodological detailsprospective, cross-sectional
- Prospective
- Cross-sectional
Performance
As reported in the abstract
Pain response of 0 at the foot dorsum for detecting DFU-related LON
Sensitivity
65%
Specificity
100%
PPV
100%
NPV
96%
Further findings
Median
| Outcome | Without neuropathy | DFU |
|---|---|---|
| Pain intensity at plantar side of foot (0–10) | 7 (range 0–10) | 0 (range 0–8) |
| Pain intensity at dorsal side of foot (0–10) | 8.5 (range 2–10) | 0 (range 0–10) |
Pain intensity at hands (control)
- Average pain rating by all participants
- 6
Original publication
Trial of a Trivial Quantitative Heat-Pain Stimulus for Detecting Severe Loss of Nociception. J Diabetes Sci Technol. Published 22 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →